Water → 2-(Propan-2-yl)benzene-1-sulfonyl fluoride

HRID 1899010ノート

反応式

HRID 1899010 の反応式
[CH:1]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[S:10](Cl)(=[O:12])=[O:11])([CH3:3])[CH3:2].[F-:14].[K+].O>O1CCOCC1>[CH:1]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[S:10]([F:14])(=[O:12])=[O:11])([CH3:3])[CH3:2]

参加物

5

反応物 3

HCID 962Water2 回HCID 522689Potassium FluorideHCID 129164822-(Propan-2-yl)benzene-1-sulfonyl chloride

生成物 1

HCID 233731302-(Propan-2-yl)benzene-1-sulfonyl fluoride収率 96.1%

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒

実験手順

27 g of 2-isopropylbenzenesulfonyl chloride and 22 g of KF are stirred in 75 ml of dioxane and 20 ml of water at 45° C. for 27 h and at RT for 45 h. 800 ml of water are then added, and the mixture is extracted with 3×300 ml of EA. The combined organic phases are dried over Na2SO4 and the solvent is removed in vacuo. 24 g of a colorless oil are obtained.

後処理

  1. extractionthe mixture is extracted with 3×300 ml of EA
  2. dry with materialThe combined organic phases are dried over Na2SO4
  3. customthe solvent is removed in vacuo

出典と根拠

ORDレコード
ord-f3291efbbab14b2a9a7fef2bd49b44d7
出典データセット
uspto-grants-1996_11
特許番号
US05571842

反応ノート

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