Sulfisoxazole → 1-Cyclohexyl-3-[4-[(3,4-dimethyl-1,2-oxazol-5-yl)sulfamoyl]phenyl]urea

HRID 1899690

反応式

HRID 1899690 の反応式
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([NH:11][C:12]2[O:16][N:15]=[C:14]([CH3:17])[C:13]=2[CH3:18])(=[O:10])=[O:9])=[CH:4][CH:3]=1.[CH:19]1([N:25]=[C:26]=[O:27])[CH2:24][CH2:23][CH2:22][CH2:21][CH2:20]1>>[CH:19]1([NH:25][C:26](=[O:27])[NH:1][C:2]2[CH:7]=[CH:6][C:5]([S:8]([NH:11][C:12]3[O:16][N:15]=[C:14]([CH3:17])[C:13]=3[CH3:18])(=[O:10])=[O:9])=[CH:4][CH:3]=2)[CH2:24][CH2:23][CH2:22][CH2:21][CH2:20]1

参加物

3

反応物 2

HCID 5344SulfisoxazoleHCID 18502Cyclohexyl isocyanate

生成物 1

HCID 40545201-Cyclohexyl-3-[4-[(3,4-dimethyl-1,2-oxazol-5-yl)sulfamoyl]phenyl]urea

実験手順

This compound was prepared from 4-amino-N-(3,4-dimethyl-5-isoxazolyl)benzene-sulfonamide and cyclohexyl isocyanate according to the method in Example 110 in 75% crude yield. Further purification was achieved by preparative HPLC (76% recovery), furnishing the pure product as a white solid, m.p. 190°-195° C.

後処理

  1. customFurther purification

出典と根拠

ORDレコード
ord-038f879dac3c45869fa859d2befa14a5
出典データセット
uspto-grants-1996_11
特許番号
US05571821

関連ノート

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