Benzyl Bromide → HCID 18923724、化合物
反応式
[Cl:1][C:2]1[CH:3]=[C:4]([CH:7]=[C:8]([Cl:10])[CH:9]=1)[NH:5][CH3:6].[CH2:11](Br)[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1.C(N(CC)CC)C>C(#N)C>[CH2:11]([N:5]([CH3:6])[C:4]1[CH:3]=[C:2]([Cl:1])[CH:9]=[C:8]([Cl:10])[CH:7]=1)[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1参加物
5
実験手順
The mixture of 3,5-dichloro-N-methylaniline (345 mg) and excess amount of benzyl bromide and triethylamine in acetonitrile (7 ml) was refluxed for 4 hours. The reaction mixture was separated with ethyl acetate and water, and the organic layer was washed with water, dried and concentrated in vacuo to give N-benzyl-3,5-dichloro-N-methylaniline (532 mg).
後処理
- temperaturewas refluxed for 4 hours
- customThe reaction mixture was separated with ethyl acetate and water
- washthe organic layer was washed with water
- customdried
- concentrationconcentrated in vacuo
出典と根拠
- ORDレコード
- ord-452cdeaf38954dea8814a7e87e8f77f0
- 出典データセット
- uspto-grants-1996_11
- 特許番号
- US05574042
反応ノート
読み込み中…