反応式
CS(O[CH2:6][CH:7]1[O:21][C:10]2=[C:11]3[C:16](=[C:17]([CH3:19])[CH:18]=[C:9]2[CH2:8]1)[NH:15][C:14](=[O:20])[CH:13]=[CH:12]3)(=O)=O.[I:22]([O-])(=O)=O.[Na+]>CN(C)C=O>[I:22][CH2:6][CH:7]1[O:21][C:10]2=[C:11]3[C:16](=[C:17]([CH3:19])[CH:18]=[C:9]2[CH2:8]1)[NH:15][C:14](=[O:20])[CH:13]=[CH:12]3参加物
4
反応条件
- 温度
- 100 °C
実験手順
To a solution of 2-methanesulfonyloxymethyl-5-methyl -2,3,6,7-tetrahydrofuro[2,3-f]quinoline-7-one (931 mg) in dimethylformamide (20 ml), sodium iodate (4.5 g) was added, and the mixture was stirred at 100° C. for 2 hours. After completion of the reaction, the solvent was distilled off, and the residue was purified by silica gel column chromatography (eluent: chloroform) to obtain 1 g (assayed quantitatively) of the target compound as a light yellow powder.
後処理
- customAfter completion of the reaction
- distillationthe solvent was distilled off
- customthe residue was purified by silica gel column chromatography (eluent: chloroform)
出典と根拠
- ORDレコード
- ord-070d70ff3d7840d5bf4cd059e38e424e
- 出典データセット
- uspto-grants-1996_11
- 特許番号
- US05576324
関連ノート
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