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Hydrochloric Acid → 2,3,6,7,8,9-Hexahydro-5-methyl(alpha-methylalanyl)aminomethylfuro-[2,3-f]quinoline-7-one

HRID 1900770
ノート
印刷プレビュー

反応式

HRID 1900770 の反応式
Cl.[CH3:2][C:3]1[CH:4]=[C:5]2[CH2:16][CH:15]([CH2:17][NH:18][C:19](=[O:24])[C:20]([CH3:23])([CH3:22])[NH2:21])[O:14][C:6]2=[C:7]2[C:12]=1[NH:11][C:10](=[O:13])[CH:9]=[CH:8]2.[H][H]>O.[Pd]>[CH3:2][C:3]1[CH:4]=[C:5]2[CH2:16][CH:15]([CH2:17][NH:18][C:19](=[O:24])[C:20]([CH3:22])([CH3:23])[NH2:21])[O:14][C:6]2=[C:7]2[C:12]=1[NH:11][C:10](=[O:13])[CH2:9][CH2:8]2
参加物実験手順後処理出典と根拠反応ノート

参加物

6

反応物 3

HCID 313Hydrochloric AcidHCID 233697105-Methyl-2-(alpha-methylalanyl)aminomethyl-2,3,6,7-tetrahydrofuro-[2,3-f]quinoline-7-oneHCID 178418361HCID 178418361、化合物

生成物 1

HCID 867499952,3,6,7,8,9-Hexahydro-5-methyl(alpha-methylalanyl)aminomethylfuro-[2,3-f]quinoline-7-one収率 82%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒
HCID 962
Water
溶媒

実験手順

A hydrochloric acid salt of 5-methyl-2-(α-methylalanyl)aminomethyl-2,3,6,7-tetrahydrofuro-[2,3-f]quinoline-7-one (1.15 g, 3.27 mmol) was dissolved in water (30 ml). To the obtained solution, 10% palladium-on-carbon (1.15 g) was added, followed by stirring at 80° C. for 3.5 hours in the atmosphere of hydrogen. The reaction mixture was filtered, and the filtrate was condensed under reduced pressure. The resultant residue was subjected to a recrystallization procedure using methanol--ether to obtain 851 mg of the title compound as colorless powdery crystals (73.5%).

後処理

  1. filtrationThe reaction mixture was filtered
  2. customcondensed under reduced pressure
  3. customThe resultant residue was subjected to a recrystallization procedure

出典と根拠

ORDレコード
ord-1f2c2a88dfc54b5a8bb0084a4b19bf38
出典データセット
uspto-grants-1996_11
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US05576324

反応ノート

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