Hydrochloric Acid → HCID 67802137、化合物

HRID 1900816ノート

反応式

HRID 1900816 の反応式
[ClH:1].[NH2:2][CH2:3][C:4]1([CH3:20])[O:19][C:7]2=[C:8]3[C:13](=[C:14]([CH3:16])[CH:15]=[C:6]2[CH2:5]1)[NH:12][C:11](=[O:17])[C:10]([CH3:18])=[CH:9]3.[H][H]>O.CO.[Pd]>[NH2:2][CH2:3][C:4]1([CH3:20])[O:19][C:7]2=[C:8]3[C:13](=[C:14]([CH3:16])[CH:15]=[C:6]2[CH2:5]1)[NH:12][C:11](=[O:17])[CH:10]([CH3:18])[CH2:9]3.[ClH:1]

参加物

7

反応物 3

HCID 313Hydrochloric AcidHCID 23369839HCID 23369839、化合物HCID 178418361HCID 178418361、化合物

生成物 1

HCID 67802137HCID 67802137、化合物収率 80.6%

試薬・触媒・溶媒 3

HCID 23938Palladium触媒HCID 887Methanol溶媒HCID 962Water溶媒

実験手順

A hydrochloric acid salt of 2-Aminomethyl-2,5,8-trimethyl-2,3,6,7-tetrahydrofuro-[2,3-f]quinoline-7-one (1.18 g, 4.0 mmol) was suspended in a mixture of water (200 ml) and methanol (40 ml), to which 10% palladium-on-carbon (1.2 g) was added. The mixture was then stirred in a bath at 80° C. for 16 hours in the atmosphere of hydrogen. Post-treatment and recrystallization (methanol-ether) were performed in a manner similar to that described in Example 280 to obtain 957 mg of the title compound as colorless crystals (80.6%).

後処理

  1. additionwas added
  2. customPost-treatment and recrystallization (methanol-ether)

出典と根拠

ORDレコード
ord-dc36d9c7368c4c9fb568c254c955af51
出典データセット
uspto-grants-1996_11
特許番号
US05576324

反応ノート

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