N-bromobutanimide → HCID 23369560、化合物

反応式

[CH2:1]([C:3]1[C:4](=[O:19])[NH:5][C:6]2[C:11]([CH:12]=1)=[C:10]([OH:13])[C:9]([CH2:14][C:15]([CH3:17])=[CH2:16])=[CH:8][C:7]=2[CH3:18])[CH3:2].[Br:20]N1C(=O)CCC1=O>C(Cl)(Cl)Cl.CCCCCC>[Br:20][CH2:16][C:15]1([CH3:17])[O:13][C:10]2=[C:11]3[C:6](=[C:7]([CH3:18])[CH:8]=[C:9]2[CH2:14]1)[NH:5][C:4](=[O:19])[C:3]([CH2:1][CH3:2])=[CH:12]3

参加物

実験手順

Using 3-ethyl-6-(2-methyl-2-propenyl)-5-hydroxy-8-methylcarbostyril (710 mg, 2.76 mmol) and N-bromosuccinimide (516 mg, 2.90 mmol), the procedure of Example 227 was followed (reaction, post-treatment, and recrystallization from chloroform-n-hexane) to obtain 920 mg of the title compound as pale yellow crystals (99.2%).