1,4-Dibenzylpiperidin-4-ol → 4-Benzyl-4-piperidinol
反応式
C([N:8]1[CH2:13][CH2:12][C:11]([CH2:15][C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)([OH:14])[CH2:10][CH2:9]1)C1C=CC=CC=1.[H][H]>[Pd].C(O)C>[CH2:15]([C:11]1([OH:14])[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]1)[C:16]1[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=1参加物
5
実験手順
A mixture of N-benzyl-4-benzyl-4-piperidinol (2.0 g, 7.1 mmol) and 10% palladium on charcoal catalyst (0.5 g) in absolute ethanol (100 ml), was stirred vigorously at 40° C. under a balloon of hydrogen for 5 h. The reaction mixture was then filtered through a pad of Celite and the filtrate concentrated in vacuo to a grayish solid. This material was dissolved in methanol and filtered a second time through Celite and the filtrate concentrated in vacuo to the product, a white solid.
後処理
- filtrationThe reaction mixture was then filtered through a pad of Celite
- concentrationthe filtrate concentrated in vacuo to a grayish solid
- dissolutionThis material was dissolved in methanol
- filtrationfiltered a second time through Celite
- concentrationthe filtrate concentrated in vacuo to the product
出典と根拠
- ORDレコード
- ord-b57c6caebf254421a1e6d52301a68676
- 出典データセット
- uspto-grants-1996_11
- 特許番号
- US05576313
反応ノート
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