Tetrabutylammonium Fluoride → 4-(3-Pyrrolyl)-7-bromocoumarin

HRID 1901130ノート

反応式

HRID 1901130 の反応式
[Br:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6]([C:13]3[CH:17]=[CH:16][N:15]([Si](C(C)C)(C(C)C)C(C)C)[CH:14]=3)=[CH:7][C:8](=[O:12])[O:9]2)=[CH:4][CH:3]=1.[N+](CCCC)(CCCC)(CCCC)CCCC.[F-]>C1COCC1.CCOC(C)=O>[NH:15]1[CH:16]=[CH:17][C:13]([C:6]2[C:5]3[C:10](=[CH:11][C:2]([Br:1])=[CH:3][CH:4]=3)[O:9][C:8](=[O:12])[CH:7]=2)=[CH:14]1

参加物

5

反応物 2

HCID 2724141Tetrabutylammonium FluorideHCID 23370193HCID 23370193、化合物

生成物 1

HCID 233702084-(3-Pyrrolyl)-7-bromocoumarin

試薬・触媒・溶媒 2

HCID 8028Tetrahydrofuran溶媒2 回HCID 8857Ethyl Acetate溶媒

実験手順

To a solution of the silyl compound from Step 1 (42 mg, 0.094 mmol) in THF (1 mL) was added Bu4NF 1M in THF (94 (L, 0.094 mmol) and the reaction mixture was stirred at r.t. for 15 min. The mixture was diluted with EtOAc, washed with brine, dried over MgSO4, filtered and evaporated to give the title compound as an oil.

後処理

  1. washwashed with brine
  2. dry with materialdried over MgSO4
  3. filtrationfiltered
  4. customevaporated

出典と根拠

ORDレコード
ord-9f4ea5b90d4e413d8ac8e53754a6f40e
出典データセット
uspto-grants-1996_11
特許番号
US05576338

反応ノート

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