1-Azido-3-(benzyloxy)propan-2-ol → 1-Amino-3-(benzyloxy)propan-2-ol

HRID 1901701ノート

反応式

HRID 1901701 の反応式
[CH2:1]([O:8][CH2:9][CH:10]([OH:15])[CH2:11][N:12]=[N+]=[N-])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[H-].[Al+3].[Li+].[H-].[H-].[H-]>O1CCCC1>[CH2:1]([O:8][CH2:9][CH:10]([OH:15])[CH2:11][NH2:12])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

4

反応物 2

HCID 132105261-Azido-3-(benzyloxy)propan-2-olHCID 21226445Aluminium lithium hydride

生成物 1

HCID 3427951-Amino-3-(benzyloxy)propan-2-ol収率 70.2%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

A procedure similar to that described in Preparation 13 was repeated, except that 5.7 g of 3-benzyloxy-2-hydroxypropylazide (prepared as described in Preparation 47), 2.09 g of lithium aluminum hydride and 250 ml of anhydrous tetrahydrofuran were used, to give 3.5 g of the title compound as white crystals, melting at 72° C. to 74° C.

後処理

  1. customA procedure similar to that described in Preparation 13

出典と根拠

ORDレコード
ord-f6f9e33daaeb4bfc9c91e53a79f446ce
出典データセット
uspto-grants-1996_11
特許番号
US05578620

反応ノート

読み込み中…