Methanol → 3-Phenylthio-2-hydroxypropylazide

HRID 1901735ノート

反応式

HRID 1901735 の反応式
[C:1]1([S:7][CH2:8][CH:9]2[CH2:11][O:10]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[N-:12]=[N+:13]=[N-:14].[Na+].C(OC)=O.CO>O>[C:1]1([S:7][CH2:8][CH:9]([OH:10])[CH2:11][N:12]=[N+:13]=[N-:14])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

参加物

6

反応物 4

HCID 887MethanolHCID 7865Methyl formateHCID 33557Sodium AzideHCID 110949982-((Phenylsulfanyl)methyl)oxirane

生成物 1

HCID 214747633-Phenylthio-2-hydroxypropylazide収率 91.9%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A procedure similar to that described in Preparation 12 was repeated, except that 7.2 g of phenylthiomethyloxirane (prepared as described in preparation 85), 14 g of sodium azide, 65 ml of methyl formate and 270 ml of an 8:1 by volume mixture of methanol and water were used, to give 8.33 g of the title compound as a colorless oil having an Rf value of 0.23 (on silica gel thin layer chromatography, using a 1:10 by volume mixture of ethyl acetate and hexane as the developing solvent).

後処理

  1. customA procedure similar to that described in Preparation 12

出典と根拠

ORDレコード
ord-600ee39bdfdf449685b616b39ae1306f
出典データセット
uspto-grants-1996_11
特許番号
US05578620

反応ノート

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