3-(N-Methyl-N-phenylamino)-2-hydroxypropylazide → 1-Amino-3-[methyl(phenyl)amino]propan-2-ol
反応式
[H][H].[CH3:3][N:4]([CH2:11][CH:12]([OH:17])[CH2:13][N:14]=[N+]=[N-])[C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1>[Pd].C(O)C>[CH3:3][N:4]([CH2:11][CH:12]([OH:17])[CH2:13][NH2:14])[C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1参加物
5
実験手順
Hydrogen was introduced into a mixture of 1.85 g of 3-(N-methyl-N-phenylamino)-2-hydroxypropylazide (prepared as described in Preparation 89), 0.9 g of 10% w/w palladium-on-carbon and 30 ml of ethanol for 1.5 hours. At the end of this time, the atmosphere was replaced with nitrogen, the palladium-on-carbon catalyst was removed from the reaction mixture by filtration, and the filtrate was concentrated by evaporation under reduced pressure, to give 1.6 g of the title compound which decomposed at 136° C.
後処理
- customthe palladium-on-carbon catalyst was removed from the reaction mixture by filtration
- concentrationthe filtrate was concentrated by evaporation under reduced pressure
出典と根拠
- ORDレコード
- ord-0fad934a0c6d4bb6868b47aec2ad675e
- 出典データセット
- uspto-grants-1996_11
- 特許番号
- US05578620
反応ノート
読み込み中…