Boron tribromide → HCID 23368791、化合物

HRID 1901793

反応式

HRID 1901793 の反応式
C[O:2][C:3](=[O:24])[CH2:4][C:5]1[C:13]2[C:8](=[CH:9][CH:10]=[C:11]([OH:14])[CH:12]=2)[N:7]([CH2:15][C:16]2[CH:21]=[CH:20][C:19]([Cl:22])=[CH:18][CH:17]=2)[C:6]=1[CH3:23].ClC1C=CC(CN2C3C(=CC(OC)=CC=3)C(CC(O)=O)=C2C)=CC=1.B(Br)(Br)Br>C(Cl)Cl>[Cl:22][C:19]1[CH:18]=[CH:17][C:16]([CH2:15][N:7]2[C:8]3[C:13](=[CH:12][C:11]([OH:14])=[CH:10][CH:9]=3)[C:5]([CH2:4][C:3]([OH:24])=[O:2])=[C:6]2[CH3:23])=[CH:21][CH:20]=1

参加物

5

反応物 3

HCID 25134Boron tribromideHCID 40598951-(4-Chlorobenzyl)-5-methoxy-2-methylindole-3-acetic acidHCID 53817482HCID 53817482、化合物

生成物 1

HCID 23368791HCID 23368791、化合物

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

1-[(4-Chlorophenyl)methyl]-5-hydroxy-2-methyl-1H-indole-3-acetic acid methyl ester. Using the methods in Example 63, Part C, 1.2 g (3.5 mmol) of 1-[(4-chlorophenyl)methyl]-5-methoxy-2-methyl-1H-indole-3-acetic acid was treated with 15 mL of 1M BBr3 in CH2Cl2 to give crude 1-[(4-chlorophenyl)-methyl]-5-hydroxy-2-methyl-1H-indole-3-acetic acid which was treated with sulfuric acid in MeOH to give 1.2 g of 1-[(4-chlorophenyl)methyl]-5-hydroxy-2-methyl-1H-indole-3-acetic acid methyl ester.

出典と根拠

ORDレコード
ord-3236222f72e941c788dc77e1abfa8ce4
出典データセット
uspto-grants-1996_11
特許番号
US05578634

関連ノート

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