Trifluoroacetic acid → Spiro[1H-indene-1,4'-piperidin]-3(2H)-one trifluoroacetamide
反応式
C(OC([N:8]1[CH2:13][CH2:12][C:11]2([C:21]3[CH:16]([CH2:17][CH:18]=[CH:19][CH:20]=3)[C:15](=[O:22])[CH2:14]2)[CH2:10][CH2:9]1)=O)(C)(C)C.[F:23][C:24]([F:29])([F:28])[C:25](O)=[O:26].C1(OC)C=CC=CC=1>ClCCl>[F:23][C:24]([F:29])([F:28])[C:25]([NH2:8])=[O:26].[NH:8]1[CH2:13][CH2:12][C:11]2([C:21]3[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=3)[C:15](=[O:22])[CH2:14]2)[CH2:10][CH2:9]1参加物
5
実験手順
A solution of the intermediate from Step A in a 1:1:0.5 mixture of trifluoroacetic acid, dichloromethane and anisole was stirred for 1 hour and then concentrated and azeotroped from toluene to give the title compound.
後処理
- concentrationconcentrated
- customazeotroped from toluene
出典と根拠
- ORDレコード
- ord-23a0414e077d4226beee648f0b9d5abe
- 出典データセット
- uspto-grants-1996_11
- 特許番号
- US05578593
反応ノート
読み込み中…