Hydrogen Bromide → (R)-2-Amino-4-(4-hydroxyphenyl)butanoic acid hydrobromide
反応式
COC([NH:5][C@H:6]([CH2:10][CH2:11][C:12]1[CH:17]=[CH:16][C:15]([O:18]C)=[CH:14][CH:13]=1)[C:7]([OH:9])=[O:8])=O.[BrH:20]>C(O)(=O)C>[BrH:20].[OH:18][C:15]1[CH:14]=[CH:13][C:12]([CH2:11][CH2:10][C@@H:6]([NH2:5])[C:7]([OH:9])=[O:8])=[CH:17][CH:16]=1参加物
4
実験手順
A solution of (2R)-2-[(methoxycarbonyl)amino]-4-(4-methoxyphenyl)-butanoic acid (5.0 g, 18.7 mmol) in 5 mL of 30% HBr in acetic acid was heated at 60° C. overnight. The reaction mixture was cooled to room temperature and the solvent was removed under reduced pressure to give the title compound as an orange solid.
後処理
- customthe solvent was removed under reduced pressure
出典と根拠
- ORDレコード
- ord-cd495096f60c472b8b6e9f5ce78a2d6a
- 出典データセット
- uspto-grants-1996_11
- 特許番号
- US05578593
反応ノート
読み込み中…