Benzaldehyde → 3-(1H-Benzimidazol-1-yl)-N-benzylpropan-1-amine

HRID 1902459ノート

反応式

HRID 1902459 の反応式
[H][H].[N:3]1([CH2:12][CH2:13][CH2:14][NH2:15])[C:7]2[CH:8]=[CH:9][CH:10]=[CH:11][C:6]=2[N:5]=[CH:4]1.[CH:16](=O)[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1>[Pd].C(O)C>[CH2:16]([NH:15][CH2:14][CH2:13][CH2:12][N:3]1[C:7]2[CH:8]=[CH:9][CH:10]=[CH:11][C:6]=2[N:5]=[CH:4]1)[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1

参加物

6

反応物 3

HCID 240BenzaldehydeHCID 39208493-(1H-1,3-benzodiazol-1-yl)propan-1-amineHCID 178418361HCID 178418361、化合物2 回

生成物 1

HCID 204690543-(1H-Benzimidazol-1-yl)-N-benzylpropan-1-amine

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒2 回

実験手順

0.5 Gram of 10% palladium on charcoal was prehydrogenated in 100 ml. of absolute ethanol until the uptake of hydrogen stopped. Then, a solution of 10 grams of 1H-benzimidazole-1-propanamine and 6.7 grams of benzaldehyde in 50 ml. of absolute ethanol was added and the mixture was stirred at atmospheric pressure and room temperature under hydrogen until the calculated amount of hydrogen was taken up. The catalyst was then removed by filtration and the solvent was evaporated to leave N-benzyl-1H-benzimidazole-1-propanamine as a colorless oil. This material was sufficiently pure for further reaction but, if desired, a pure sample could be obtained by column chromatography on silica gel.

後処理

  1. customThe catalyst was then removed by filtration
  2. customthe solvent was evaporated

出典と根拠

ORDレコード
ord-5ab23850e9a44aa79a3e87306aef8c55
出典データセット
uspto-grants-1982_12
特許番号
US04363808

反応ノート

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