5-Nitro-3-isoquinolinecarboxylic acid → 5-Aminoisoquinoline-3-carboxylic acid
反応式
[N+:1]([C:4]1[CH:13]=[CH:12][CH:11]=[C:10]2[C:5]=1[CH:6]=[C:7]([C:14]([OH:16])=[O:15])[N:8]=[CH:9]2)([O-])=O>CO.[Pd]>[NH2:1][C:4]1[CH:13]=[CH:12][CH:11]=[C:10]2[C:5]=1[CH:6]=[C:7]([C:14]([OH:16])=[O:15])[N:8]=[CH:9]2参加物
4
実験手順
5-Nitroisoquinoline-3-carboxylic acid (44 g) is dissolved in methanol (3 liters), and a catalyst consisting of palladium-on-carbon (3/97 by weight; 15 g) is added. The mixture is hydrogenated at atmospheric pressure, at a temperature between 20° and 25° C. After stirring for 5 hours, the volume of hydrogen absorbed is 13.9 liters. The mixture is filtered through diatomaceous silica and the filtrate is concentrated to dryness under reduced pressure (20 mm Hg; 2.7 kPa) at 60° C. to yield 5-aminoisoquinoline-3-carboxylic acid (35 g).
後処理
- additionis added
- customis hydrogenated at atmospheric pressure, at a temperature between 20° and 25° C
- customthe volume of hydrogen absorbed
- filtrationThe mixture is filtered through diatomaceous silica
- concentrationthe filtrate is concentrated to dryness under reduced pressure (20 mm Hg; 2.7 kPa) at 60° C.
出典と根拠
- ORDレコード
- ord-f408aa0ee97740cc8926906d0cd84de3
- 出典データセット
- uspto-grants-1982_12
- 特許番号
- US04363909
反応ノート
読み込み中…