Sodium Hydroxide → 2-Pyrrolidinone, 1-(8-quinolinyl)-

HRID 1902824

反応式

HRID 1902824 の反応式
Cl[CH2:2][CH2:3][CH2:4][C:5]([NH:7][C:8]1[CH:9]=[CH:10][CH:11]=[C:12]2[C:17]=1[N:16]=[CH:15][CH:14]=[CH:13]2)=[O:6].[OH-].[Na+]>[Cl-].C([N+](CC)(CC)CC)C1C=CC=CC=1.C(Cl)Cl>[N:16]1[C:17]2[C:12](=[CH:11][CH:10]=[CH:9][C:8]=2[N:7]2[CH2:2][CH2:3][CH2:4][C:5]2=[O:6])[CH:13]=[CH:14][CH:15]=1

参加物

5

反応物 2

HCID 14798Sodium HydroxideHCID 128985464-chloro-N-(8-quinolyl)butyramide

生成物 1

HCID 30614652-Pyrrolidinone, 1-(8-quinolinyl)-収率 90%

試薬・触媒・溶媒 2

HCID 66133Benzyl triethylammonium chloride触媒HCID 6344Dichloromethane溶媒2 回

実験手順

A solution of 4-chloro-N-(8-quinolyl)butyramide (2.5 g, 0.01 mole) and benzyltriethyl ammonium chloride (0.115 g, 5 mole%) in methylene chloride (30 ml) was stirred at room temperature. A solution of 30% aqueous sodium hydroxide (10 ml) was added and the mixture was stirred for 16 hours. The reaction mixture was then diluted with methylene chloride, the organic layer was drawn off and washed with a saturated salt solution, dried over sodium sulphate and evaporated to a solid residue. The residue was recrystallized from methylene chloride/petroleum ether to afford 1-(8-quinolyl)-2-pyrrolidinone which was identical by tlc and NMR in comparison with the product of Example 1, yield 90%.

後処理

  1. washwashed with a saturated salt solution
  2. dry with materialdried over sodium sulphate
  3. customevaporated to a solid residue
  4. customThe residue was recrystallized from methylene chloride/petroleum ether

出典と根拠

ORDレコード
ord-5e46261967d34ef6bd36697eb14215cf
出典データセット
uspto-grants-1982_12
特許番号
US04366158

関連ノート

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