Isobutylamine → HCID 178448425、化合物

HRID 1902857ノート

反応式

HRID 1902857 の反応式
Cl.CS[C:4]1[NH:5][CH2:6][C:7]([CH3:10])([CH3:9])[N:8]=1.[CH3:11][CH:12]([CH3:15])[CH2:13][NH2:14].ClC1C=[CH:23][C:20]([CH2:21][NH2:22])=[CH:19]C=1.[N:25](=[C:27]([C:33]#[N:34])[C:28]([O:30]CC)=[O:29])[OH:26].S(S([O-])(=O)=O)([O-])(=O)=O.[Na+].[Na+].[OH-].[Na+]>C(O)=O>[NH2:34][C:33]1[N:14]([CH2:13][CH:12]([CH3:15])[CH3:11])[C:4]2[N:5]([CH2:6][C:7]([CH3:10])([CH3:9])[N:8]=2)[C:28](=[O:29])[C:27]=1[N:25]=[O:26].[CH3:23][CH:20]([CH3:19])[CH2:21][N:22]1[C:33]2[NH:34][CH:11]=[N:25][C:27]=2[C:28](=[O:30])[N:5]2[CH2:6][C:7]([CH3:10])([CH3:9])[N:8]=[C:4]12

参加物

8

反応物 6

HCID 6558IsobutylamineHCID 14798Sodium HydroxideHCID 660364-ChlorobenzylamineHCID 146045Sodium dithionateHCID 6399078Ethyl 2-cyano-2-(hydroxyimino)acetateHCID 1785034432-Methylthio-4,4-dimethyl-2-imidazoline hydrochloride

生成物 1

HCID 178448425HCID 178448425、化合物

試薬・触媒・溶媒 1

HCID 284Formic Acid溶媒

実験手順

6,7-DIHYDRO-4-(2-METHYLPROPYL)-6,6-DIMETHYL-3H-IMIDAZO[1,2-a]PURIN-9(4H)-ONE 7-Amino-2,3-dihydro-2,2-dimethyl-8-(2-methylpropyl)-6-nitrosoimidazo[1,2-a]pyrimidin-5(8H)-one was prepared by reaction of the 2-methylthio-4,4-dimethyl-2-imidazoline hydrochloride with 2-methylpropylamine according to the method of Procedure 103 by substitution of the latter for p-chlorobenzylamine. The reaction product from this step was then condensed with ethyl oximinocyanoacetate as described in Procedure 103. The resulting nitroso compound was then reduced with sodium dithionate in formic acid and the resulting formylamino compound was cyclized with dilute aqueous sodium hydroxide according to Procedure 100.

出典と根拠

ORDレコード
ord-4b1607b80beb4b8eacb663c19608eb6f
出典データセット
uspto-grants-1982_12
特許番号
US04366156

反応ノート

読み込み中…