Hydrochloric Acid → HCID 568802、化合物

HRID 1903015ノート

反応式

HRID 1903015 の反応式
[C:1]1([N:7]2[C:10](=[O:11])[CH2:9][CH:8]2[C:12](OCC)=[O:13])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Cl.P([O-])([O-])(O)=O.[Na+].[Na+]>CO>[C:1]1([N:7]2[CH:8]([CH2:12][OH:13])[CH2:9][C:10]2=[O:11])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 24203Sodium Phosphate, DibasicHCID 12479106HCID 12479106、化合物

生成物 1

HCID 568802HCID 568802、化合物収率 76%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

To a dilution of 106.5 g. (0.486 moles) of ethyl 1-phenyl-4-oxo-2-azetidine-carboxylate prepared according to Example 24 in 700 ml. of methanol 18.74 g. (0.493 moles) of sodium tetrahydrido-borate(III) are added with outer cooling with ice water and stirring. The mixture is acidified with dilute hydrochloric acid and it is then neutralized with disodium hydrogenphosphate. Methanol is distilled off in vacuo. 65 g. (76%) of the named compound are obtained, melting at 100° to 102° C. (ethyl acetate/petroleum ether).

後処理

  1. distillationMethanol is distilled off in vacuo

出典と根拠

ORDレコード
ord-7156552f74684ac7bda19e085ce9e4ce
出典データセット
uspto-grants-1984_03
特許番号
US04435322

反応ノート

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