Ethanolamine → 1-(2-Hydroxyethyl)-3-phenylurea

HRID 1903289

反応式

HRID 1903289 の反応式
[CH2:1]([CH2:3][NH2:4])[OH:2].[SH2]=N.[C:7]1([NH:13][C:14](C2C=CC=CC=2C(O)=O)=[O:15])[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1>CC(C)=O>[C:7]1([NH:13][C:14]([NH:4][CH2:3][CH2:1][OH:2])=[O:15])[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1

参加物

4

反応物 2

HCID 700EthanolamineHCID 178514671HCID 178514671、化合物

生成物 1

HCID 773521-(2-Hydroxyethyl)-3-phenylurea収率 26.9%

試薬・触媒・溶媒 1

HCID 180Acetone溶媒2 回

実験手順

A solution of 0.65 g ethanolamine with 5 ml aceton was added dropwise to a suspension of 1.5 g phenylcarbamoyl-benzoic acid sulfimide with 10 ml aceton, under stirring. The reaction mixture was stirred for a further 30 minutes at ambient temperature, evaporated in vacuo, the residue was triturated with 20 ml water, and the obtained solid product was filtered, dried and recrystallized. There was obtained 0.25 g 1-phenyl-3-(2-hydroxyethyl)-urea, melting at 120°-122° C.

後処理

  1. stirringThe reaction mixture was stirred for a further 30 minutes at ambient temperature
  2. customevaporated in vacuo
  3. customthe residue was triturated with 20 ml water
  4. filtrationthe obtained solid product was filtered
  5. customdried
  6. customrecrystallized

出典と根拠

ORDレコード
ord-6a4bc0185b8a4f68ba06f1ee91d1b5f7
出典データセット
uspto-grants-1984_03
特許番号
US04435567

関連ノート

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