Acetone → N-Phenyl-N'-2-pyridinylurea

HRID 1903293

反応式

HRID 1903293 の反応式
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][N:3]=1.C(N(CC)CC)C.CC(C)=O.[SH2]=N.[C:21]1([NH:27][C:28](C2C=CC=CC=2C(O)=O)=[O:29])[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1>O>[C:21]1([NH:27][C:28]([NH:1][C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][N:3]=2)=[O:29])[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1

参加物

6

反応物 4

HCID 180Acetone2 回HCID 8471TriethylamineHCID 104392-AminopyridineHCID 178514671HCID 178514671、化合物

生成物 1

HCID 221427N-Phenyl-N'-2-pyridinylurea収率 54.5%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A solution of 0.5 g aminopyridin and 0.7 ml triethylamine with 5 ml acetone was added dropwise to a suspension of 1.5 g phenylcarbamoyl-benzoic acid sulfimide with 15 ml aceton, under stirring. The reaction mixture was stirred for 45 minutes at room temperature, then diluted with 100 ml water. The acetone was distilled off, the residue was cooled, and the precipitated solid product was filtered, washed with water and dried. 0.6 g 1-phenyl-3-(2-pyridyl)-urea was obtained with a melting point of 185°-186° C.

後処理

  1. stirringThe reaction mixture was stirred for 45 minutes at room temperature
  2. distillationThe acetone was distilled off
  3. temperaturethe residue was cooled
  4. filtrationthe precipitated solid product was filtered
  5. washwashed with water
  6. customdried

出典と根拠

ORDレコード
ord-68a5453750874c93b78d6537cfc727aa
出典データセット
uspto-grants-1984_03
特許番号
US04435567

関連ノート

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