1,5-Dibromopentane → 2-Amino-5-piperidinomethylpyrrolo[2,3-d]pyrimidin-4-one

反応式

[NH2:1][C:2]1[N:7]=[C:6]2[N:8]=[CH:9][C:10]([CH2:11][NH2:12])=[C:5]2[C:4](=[O:13])[N:3]=1.Br[CH2:15][CH2:16][CH2:17][CH2:18][CH2:19]Br.[OH-].[Na+]>CO>[NH2:1][C:2]1[N:7]=[C:6]2[N:8]=[CH:9][C:10]([CH2:11][N:12]3[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]3)=[C:5]2[C:4](=[O:13])[N:3]=1

参加物

実験手順

In 4.5 ml of methanol were dissolved 151 mg of 2-amino-5-aminomethylpyrrolo[2,3-d]pyrimidin-4-one (dihydrochloride) and 138 mg of 1,5-dibromopentane, followed by addition of 2.4 ml of 1 N-sodium hydroxide. The mixture was stirred at room temperature for 4 days. The solvent was then distilled off under pressure and the residue was purified by silica gel column chromatography. The fractions containing the desired compound were pooled and after addition of an excess of hydrogen chloride/ethanol, concentrated to dryness, followed by precipitation with ether to give 45 mg of the desired compound.