2-Propenal, 3-[4-(1,1-dimethylethyl)phenyl]-2-methyl- → Lilial

HRID 1903318

反応式

HRID 1903318 の反応式
[C:1]([C:5]1[CH:10]=[CH:9][C:8]([CH:11]=[C:12]([CH:14]=[O:15])[CH3:13])=[CH:7][CH:6]=1)([CH3:4])([CH3:3])[CH3:2].[H][H]>O.[Pd]>[C:1]([C:5]1[CH:6]=[CH:7][C:8]([CH2:11][CH:12]([CH3:13])[CH:14]=[O:15])=[CH:9][CH:10]=1)([CH3:4])([CH3:2])[CH3:3]

参加物

5

反応物 2

HCID 1146592-Propenal, 3-[4-(1,1-dimethylethyl)phenyl]-2-methyl-HCID 178418361HCID 178418361、化合物

生成物 1

HCID 228987Lilial収率 88.9%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 962Water溶媒

反応条件

温度
110 °C

実験手順

1420 g of 1-(p-tert.butylphenyl)-2-formyl-1-propene, prepared as described in paragraph (e), are mixed together with 6 g of 5% palladium/carbon and 6.8 g of soda in 20 ml of water at 70°-75° C. in a stirring autoclave. The autoclave is charged with hydrogen (8 atmospheres) and heated to 110° C. About 230 liters of hydrogen are absorbed after 12 hours. The crude 3-(p-tert.butyl-phenyl)-2-methyl-propionaldehyde is treated with ether, washed neutral with water and dried over sodium sulphate. After removing the ether, the product is fractionally distilled in vacuo. After separating a first running and a last running, there are obtained 1275 g of 3-(p-tert.butylphenyl)-2-methyl-propionaldehyde in 95% purity (about 88% of theory). Boiling point: 150°-152° C./15 mmHg; nD20 =1.5050.

後処理

  1. customAbout 230 liters of hydrogen are absorbed after 12 hours
  2. additionThe crude 3-(p-tert.butyl-phenyl)-2-methyl-propionaldehyde is treated with ether
  3. washwashed neutral with water
  4. dry with materialdried over sodium sulphate
  5. customAfter removing the ether
  6. distillationthe product is fractionally distilled in vacuo
  7. customAfter separating a first running

出典と根拠

ORDレコード
ord-41740ed71faf4bc78ef173ba5d954b0f
出典データセット
uspto-grants-1984_03
特許番号
US04435585

関連ノート

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