Sulfuric Acid → 6-(22-Hydroxydocosyl)-2,3-dimethoxy-5-methylphenol

HRID 1903424ノート

反応式

HRID 1903424 の反応式
[OH:1][C:2]1[C:7]([O:8][CH3:9])=[C:6]([O:10][CH3:11])[CH:5]=[C:4]([CH3:12])[C:3]=1[CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][C:34](OC)=[O:35].[H-].[Al+3].[Li+].[H-].[H-].[H-].S(=O)(=O)(O)O>O1CCCC1>[OH:35][CH2:34][CH2:33][CH2:32][CH2:31][CH2:30][CH2:29][CH2:28][CH2:27][CH2:26][CH2:25][CH2:24][CH2:23][CH2:22][CH2:21][CH2:20][CH2:19][CH2:18][CH2:17][CH2:16][CH2:15][CH2:14][CH2:13][C:3]1[C:2]([OH:1])=[C:7]([O:8][CH3:9])[C:6]([O:10][CH3:11])=[CH:5][C:4]=1[CH3:12]

参加物

5

反応物 3

HCID 1118Sulfuric AcidHCID 12824096HCID 12824096、化合物HCID 21226445Aluminium lithium hydride

生成物 1

HCID 128241256-(22-Hydroxydocosyl)-2,3-dimethoxy-5-methylphenol

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

To 30 ml of a solution of 3 g of methyl 22-(2-hydroxy-3,4-dimethoxy-6-methylphenyl)docosanoate in tetrahydrofuran is added lithium aluminum hydride, and the mixture is stirred at room temperature for 1 hour. To the reaction mixture is added 10% sulfuric acid under ice cooling, and the whole mixture is extracted with ether. The extract is washed with water and dried, and then the solvent is distilled off under reduced pressure to give colorless crystals of 6-(22-hydroxydocosyl)-2,3-dimethoxy-5-methylphenol.

後処理

  1. extractionthe whole mixture is extracted with ether
  2. washThe extract is washed with water
  3. customdried
  4. distillationthe solvent is distilled off under reduced pressure

出典と根拠

ORDレコード
ord-b5fadfd1ff434de2b7992b5822f2ffda
出典データセット
uspto-grants-1984_03
特許番号
US04436753

反応ノート

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