p-Toluenesulfonic acid → Ethyl 4-oxotetrahydrothiophene-3-carboxylate

HRID 1903639ノート

反応式

HRID 1903639 の反応式
[O:1]=[C:2]1[CH:6]([C:7]([O:9][CH3:10])=[O:8])[CH2:5][S:4][CH2:3]1.[C:11]1(C)C=CC(S(O)(=O)=O)=CC=1>C(O)C>[O:1]=[C:2]1[CH:6]([C:7]([O:9][CH2:10][CH3:11])=[O:8])[CH2:5][S:4][CH2:3]1

参加物

4

反応物 2

HCID 6101p-Toluenesulfonic acidHCID 984243-Thiophenecarboxylic acid, tetrahydro-4-oxo-, methyl ester

生成物 1

HCID 310629Ethyl 4-oxotetrahydrothiophene-3-carboxylate

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

20 parts by weight of methyl 3-keto-1,5-dihydrothiophene-4-carboxylate, 57.8 parts by weight of ethanol and 1 part by weight of p-toluenesulfonic acid are refluxed for 50 hours, and the mixture is then distilled. 17.1 parts by weight of ethyl 3-keto-1,5-dihydrothiophene-4-carboxylate of melting point 106°-109° C./1.3 mbar are obtained.

後処理

  1. distillationthe mixture is then distilled

出典と根拠

ORDレコード
ord-39f68d43f51041e3867a14821280d6d7
出典データセット
uspto-grants-1984_03
特許番号
US04437878

反応ノート

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