Ethyl 2-chloro-4-(trifluoromethyl)-1,3-thiazole-5-carboxylate → ethyl 2-Ethoxy-4-Trifluoromethyl-5-Thiazolecarboxylate

HRID 1903688ノート

反応式

HRID 1903688 の反応式
[O-:1][CH2:2][CH3:3].[Na+].[Na].Cl[C:7]1[S:8][C:9]([C:16]([O:18][CH2:19][CH3:20])=[O:17])=[C:10]([C:12]([F:15])([F:14])[F:13])[N:11]=1>C(O)C>[CH2:2]([O:1][C:7]1[S:8][C:9]([C:16]([O:18][CH2:19][CH3:20])=[O:17])=[C:10]([C:12]([F:14])([F:13])[F:15])[N:11]=1)[CH3:3]

参加物

5

反応物 3

HCID 1235240Ethyl 2-chloro-4-(trifluoromethyl)-1,3-thiazole-5-carboxylateHCID 2723922Sodium ethoxideHCID 5360545Sodium

生成物 1

HCID 13282763ethyl 2-Ethoxy-4-Trifluoromethyl-5-Thiazolecarboxylate収率 78%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

反応条件

温度
80 °C

実験手順

To a cold (0° C.) solution of sodium ethoxide, prepared from 0.46 g (0.02 mole) of sodium and 40 ml. of dried ethanol, was added 5.2 g (0.02 mole) of ethyl 2-chloro-4-trifluoromethyl-5-thiazolecarboxylate. A precipitate formed immediately. The reaction mixture was heated to 80° C. and then poured into ice water. The precipitate was collected to give 4.2 g (78%) of the desired product as a white solid, m.p. 30.5°-31.5° C.

後処理

  1. customA precipitate formed immediately
  2. customThe precipitate was collected

出典と根拠

ORDレコード
ord-6d3aec2e07bf48df90d86d28bfeab52e
出典データセット
uspto-grants-1984_03
特許番号
US04437876

反応ノート

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