Ethyl bromoacetate → Ethyl 2-oxo-4-phenoxy-3-benzothiazolineacetate
反応式
[O:1]=[C:2]1[NH:6][C:5]2[C:7]([O:11][C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)=[CH:8][CH:9]=[CH:10][C:4]=2[S:3]1.Br[CH2:19][C:20]([O:22][CH2:23][CH3:24])=[O:21].C(=O)([O-])[O-].[K+].[K+]>CC(C)=O>[O:1]=[C:2]1[N:6]([CH2:19][C:20]([O:22][CH2:23][CH3:24])=[O:21])[C:5]2[C:7]([O:11][C:12]3[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=3)=[CH:8][CH:9]=[CH:10][C:4]=2[S:3]1参加物
5
実験手順
A mixture of 2-oxo-4-phenoxybenzothiazoline (2.0 g), ethyl bromoacetate (1.7 g), potassium carbonate (1.4 g) in acetone (30 ml) was refluxed for an hour with stirring. After the resultant mixture was filtered, the filtrate was concentrated under reduced pressure to give a residue, which was recrystallized from a mixture of ethanol and n-hexane to give crystalline ethyl 2-oxo-4-phenoxy-3-benzothiazolineacetate (2.0 g).