Sulfuric Acid → Methyl 4-dimethylaminobenzoate

HRID 1904031

反応式

HRID 1904031 の反応式
[CH3:1][N:2]([CH3:12])[C:3]1[CH:11]=[CH:10][C:6]([C:7]([OH:9])=[O:8])=[CH:5][CH:4]=1.S(=O)(=O)(O)O.[C:18](=O)(O)[O-].[Na+]>CO>[CH3:18][O:8][C:7](=[O:9])[C:6]1[CH:10]=[CH:11][C:3]([N:2]([CH3:12])[CH3:1])=[CH:4][CH:5]=1

参加物

5

反応物 3

HCID 1118Sulfuric AcidHCID 120924-(Dimethylamino)benzoic acidHCID 516892Sodium Bicarbonate

生成物 1

HCID 70994Methyl 4-dimethylaminobenzoate

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

23 g of 4-dimethylaminobenzoic acid was dissolved in 200 ml of methanol to which was added 2 ml of concentrated sulfuric acid and the mixture was refluxed with heating for 2 days. After cooling, the reaction mixture was poured into an aqueous solution of sodium bicarbonate and the crystals thus deposited were collected by filtration, washed with water and dried to obtain 24 g of 4-dimethylaminobenzoic acid methyl ester having a melting point of 101° to 102° C.

後処理

  1. temperaturethe mixture was refluxed
  2. temperaturewith heating for 2 days
  3. temperatureAfter cooling
  4. filtrationthe crystals thus deposited were collected by filtration
  5. washwashed with water
  6. customdried

出典と根拠

ORDレコード
ord-05ee31fdce14478aabec7f1a824e6376
出典データセット
uspto-grants-1984_03
特許番号
US04439519

関連ノート

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