Ethyl 7-chloro-1H-pyrazolo[4,3-B]pyridine-6-carboxylate → ethyl 7-n-butylamino-1H-pyrazolo [4,3-b]pyridine-6-carboxylate

HRID 1904271

反応式

HRID 1904271 の反応式
Cl[C:2]1[C:7]([C:8]([O:10][CH2:11][CH3:12])=[O:9])=[CH:6][N:5]=[C:4]2[CH:13]=[N:14][NH:15][C:3]=12>C(N)CCC>[CH2:4]([NH:5][C:2]1[C:7]([C:8]([O:10][CH2:11][CH3:12])=[O:9])=[CH:6][N:5]=[C:4]2[CH:13]=[N:14][NH:15][C:3]=12)[CH2:3][CH2:2][CH3:7]

参加物

3

反応物 1

HCID 20038759Ethyl 7-chloro-1H-pyrazolo[4,3-B]pyridine-6-carboxylate

生成物 1

HCID 20038776ethyl 7-n-butylamino-1H-pyrazolo [4,3-b]pyridine-6-carboxylate収率 135.3%

試薬・触媒・溶媒 1

HCID 8007Butylamine溶媒

実験手順

Ethyl 7-chloro-1H-pyrazolo[4,3-b]pyridine-6-carboxylate (3.5 g, 15.5 mmol) was dissolved in n-butylamine (25 ml) and stirred at room temperature for 3 h. Excess butylamine was removed in vacuo and the residual solid was washed well with water, and recrystallised from ethyl acetate to give ethyl 7-n-butylamino-1H-pyrazolo [4,3-b]pyridine-6-carboxylate (2.75 g, 67%), m.p. 164°-170° C.

後処理

  1. customExcess butylamine was removed in vacuo
  2. washthe residual solid was washed well with water
  3. customrecrystallised from ethyl acetate

出典と根拠

ORDレコード
ord-c7eda3542d964d179234801c23ff0d71
出典データセット
uspto-grants-1989_06
特許番号
US04837238

関連ノート

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