Benzoyl Peroxide → Ethyl 4-(bromomethyl)-2-chlorobenzoate

HRID 1904413ノート

反応式

HRID 1904413 の反応式
[Cl:1][C:2]1[CH:12]=[C:11]([CH3:13])[CH:10]=[CH:9][C:3]=1[C:4]([O:6][CH2:7][CH3:8])=[O:5].[Br:14]N1C(=O)CCC1=O.C(OOC(=O)C1C=CC=CC=1)(=O)C1C=CC=CC=1>C(Cl)(Cl)(Cl)Cl>[Br:14][CH2:13][C:11]1[CH:10]=[CH:9][C:3]([C:4]([O:6][CH2:7][CH3:8])=[O:5])=[C:2]([Cl:1])[CH:12]=1

参加物

5

反応物 3

HCID 7187Benzoyl PeroxideHCID 67184N-bromobutanimideHCID 14459377Benzoic acid, 2-chloro-4-methyl-, ethyl ester

生成物 1

HCID 14459378Ethyl 4-(bromomethyl)-2-chlorobenzoate

試薬・触媒・溶媒 1

HCID 5943Carbon Tetrachloride溶媒

実験手順

A mixture of ethyl 2-chloro-4-methylbenzoate (2.34 g, 0.0118 mol), N-bromosuccinimide (2.05 g, 0.0115 mol), and benzoyl peroxide (0.5 g) in carbon tetrachloride (50 ml) was heated under reflux for 90 minutes. The resulting solution was filtered and the solvent was evaporated off under reduced pressure to yield ethyl 4-(bromomethyl)-2-chlorobenzoate as a yellow crystalline solid having the following structural characteristics:

後処理

  1. temperaturewas heated
  2. temperatureunder reflux for 90 minutes
  3. filtrationThe resulting solution was filtered
  4. customthe solvent was evaporated off under reduced pressure

出典と根拠

ORDレコード
ord-144559fac48f445fa7c30663345cfb4e
出典データセット
uspto-grants-1989_06
特許番号
US04837333

反応ノート

読み込み中…