Hydrochloric Acid → (2RS, 3S)-3-amino-2-hydroxy-5-methylhexyl methyl ether hydrochloride

HRID 1905321ノート

反応式

HRID 1905321 の反応式
[CH3:1][O:2][CH2:3][CH:4]([OH:21])[C@@H:5]([NH:10]C(OCC1C=CC=CC=1)=O)[CH2:6][CH:7]([CH3:9])[CH3:8].[ClH:22]>CO.[Pd]>[ClH:22].[CH3:1][O:2][CH2:3][CH:4]([OH:21])[C@@H:5]([NH2:10])[CH2:6][CH:7]([CH3:9])[CH3:8]

参加物

5

反応物 2

HCID 313Hydrochloric AcidHCID 13909435(2RS, 3S)-3-carbobenzoxyamino-2-hydroxy-5-methylhexyl methyl ether

生成物 1

HCID 86743183(2RS, 3S)-3-amino-2-hydroxy-5-methylhexyl methyl ether hydrochloride

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

To a solution of 94 mg of the ether compound obtained in 10 ml of methanol was added 0.16 ml of a 2N-hydrochloric acid, and the mixture was hydrogenated over 10 mg of a 10% palladium charcoal under hydrogen atmosphere. After filtration of the catalyst, the filtrate was evaporated under reduced pressure to obtain 54 mg of (2RS, 3S)-3-amino-2-hydroxy-5-methylhexyl methyl ether hydrochloride as a colorless viscous oil.

後処理

  1. filtrationAfter filtration of the catalyst
  2. customthe filtrate was evaporated under reduced pressure

出典と根拠

ORDレコード
ord-c156175a9a7544e6b452522edbcaa4e9
出典データセット
uspto-grants-1989_06
特許番号
US04841067

反応ノート

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