Sulfuric Acid → 4-[N-(4-Chloro-benzyl)-amino]-cyclohexanone

HRID 1905437

反応式

HRID 1905437 の反応式
[Cl:1][C:2]1[CH:16]=[CH:15][C:5]([CH2:6][NH:7][CH:8]2[CH2:13][CH2:12][CH:11]([OH:14])[CH2:10][CH2:9]2)=[CH:4][CH:3]=1.S(=O)(=O)(O)O.[Cr](O[Cr]([O-])(=O)=O)([O-])(=O)=O.[K+].[K+].[OH-].[Na+]>>[Cl:1][C:2]1[CH:16]=[CH:15][C:5]([CH2:6][NH:7][CH:8]2[CH2:9][CH2:10][C:11](=[O:14])[CH2:12][CH2:13]2)=[CH:4][CH:3]=1

参加物

5

反応物 4

HCID 1118Sulfuric AcidHCID 14798Sodium HydroxideHCID 24502Potassium DichromateHCID 136706584-(4-Chloro-benzylamino)-cyclohexanol

生成物 1

HCID 136706644-[N-(4-Chloro-benzyl)-amino]-cyclohexanone

反応条件

温度
50 °C

実験手順

23.9 g (0.1 Mol) of 4-[N-(4-chlorobenzyl)-amino]-cyclohexanol are suspended in 125 ml of ice water and 32 ml of concentrated sulphuric acid are added. Then 29.4 g (0.1 Mol) of potassium dichromate are added in 2 batches and the mixture is heated for 5 hours at 50° C. It is then cooled, made alkaline with sodium hydroxide solution and extracted with chloroform. After concentration, a yellowish oily liquid is obtained.

後処理

  1. temperatureIt is then cooled
  2. extractionextracted with chloroform
  3. concentrationAfter concentration
  4. customa yellowish oily liquid is obtained

出典と根拠

ORDレコード
ord-8cb584f7ec3f467483e6eb8542080983
出典データセット
uspto-grants-1989_06
特許番号
US04843086

関連ノート

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