Methyl iodide → 4-[N-(4-Chloro-benzyl)-methylamino]-cyclohexanone

HRID 1905438

反応式

HRID 1905438 の反応式
[Cl:1][C:2]1[CH:16]=[CH:15][C:5]([CH2:6][NH:7][CH:8]2[CH2:13][CH2:12][C:11](=[O:14])[CH2:10][CH2:9]2)=[CH:4][CH:3]=1.[C:17](=O)([O-])[O-].[K+].[K+].CI>CN(C)C=O>[Cl:1][C:2]1[CH:16]=[CH:15][C:5]([CH2:6][N:7]([CH3:17])[CH:8]2[CH2:9][CH2:10][C:11](=[O:14])[CH2:12][CH2:13]2)=[CH:4][CH:3]=1

参加物

5

反応物 3

HCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 136706644-[N-(4-Chloro-benzyl)-amino]-cyclohexanone

生成物 1

HCID 136706654-[N-(4-Chloro-benzyl)-methylamino]-cyclohexanone

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

8.4 g (35 mMol) of 4-[N-(4-chloro-benzyl)-amino]-cyclohexanone are dissolved in 50 ml of absolute dimethylformamide and, after the addition of 2.6 g (18.7 mMol) of potassium carbonate, 5.0 g (35 mMol) of methyliodide are added dropwise at 25°-30° C. After standing overnight the mixture is concentrated, mixed with water and extracted with chloroform. The extracts are dried and concentrated.

後処理

  1. additionare added dropwise at 25°-30° C
  2. concentrationthe mixture is concentrated
  3. additionmixed with water
  4. extractionextracted with chloroform
  5. customThe extracts are dried
  6. concentrationconcentrated

出典と根拠

ORDレコード
ord-5e7327042cdc4bde953ee404246f58db
出典データセット
uspto-grants-1989_06
特許番号
US04843086

関連ノート

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