Dimethylcarbamoyl Chloride → 3-Methyl-1-dimethylcarbamoyloxypyridinium chloride
反応式
[CH3:1][C:2]1[CH:3]=[N+:4]([O-:8])[CH:5]=[CH:6][CH:7]=1.[CH3:9][N:10]([CH3:14])[C:11]([Cl:13])=[O:12]>>[Cl-:13].[CH3:1][C:2]1[CH:3]=[N+:4]([O:8][C:11](=[O:12])[N:10]([CH3:14])[CH3:9])[CH:5]=[CH:6][CH:7]=1参加物
3
実験手順
Also, Fife et al., cited hereabove and Heterocycles 22:93-96(1984), reported the reaction of 3-methylpyridine-1-oxide with dimethyl-carbamoyl chloride to give 3-methyl-1-dimethylcarbamoyloxypyridinium chloride. Reaction of this pyridinium salt with potassium cyanide in water gave 3-methyl-2-cyanopyridine (89%) and the 6-isomer (11%).
出典と根拠
- ORDレコード
- ord-0ef46d27beeb4da4ad834a52dd0556e3
- 出典データセット
- uspto-grants-1989_06
- 特許番号
- US04843163
反応ノート
読み込み中…