Hydrogen Bromide → 5-hydroxy-2,3-dihydro-1H-indene-1-carboxylic acid
反応式
C[O:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[CH:8]([C:12]([OH:14])=[O:13])[CH2:7][CH2:6]2.Br>>[OH:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[CH:8]([C:12]([OH:14])=[O:13])[CH2:7][CH2:6]2参加物
3
実験手順
In a 20-liter reactor provided with a mechanical stirrer, 1.6 kg of 2,3-dihydro-5-methoxy-1H-inden-1-carboxylic acid and 8 l of 48% hydrobromic acid were introduced and heated at 135°-140° C. in oil bath for 15 hours. The mixture was allowed to cool, and the hydrobromic acid was evaporated at vacuum; to the blackish residue, 3 l of toluene were added and the solvent was evaporated at vacuum. This operation was made again with further 3 l of toluebe to give the desired compound as blackish solid, 1.5 kg (100%), m.p. 137°-138° C. and acid group titration: 101%.
後処理
- customIn a 20-liter reactor provided with a mechanical stirrer
- temperatureheated at 135°-140° C. in oil bath for 15 hours
- temperatureto cool
- customthe hydrobromic acid was evaporated at vacuum
- additionto the blackish residue, 3 l of toluene were added
- customthe solvent was evaporated at vacuum
出典と根拠
- ORDレコード
- ord-8c3949bb644a4e91b41d78ba17b89357
- 出典データセット
- uspto-grants-1989_06
- 特許番号
- US04843165
反応ノート
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