2-[4-(Benzyloxy)-2-oxo-2,5-dihydro-1H-pyrrol-1-yl]acetamide → Oxiracetam

HRID 1905547ノート

反応式

HRID 1905547 の反応式
C([O:8][C:9]1[CH2:13][N:12]([CH2:14][C:15]([NH2:17])=[O:16])[C:11](=[O:18])[CH:10]=1)C1C=CC=CC=1.[H][H]>C(O)(=O)C.[Pd].[Pt]=O>[OH:8][CH:9]1[CH2:13][N:12]([CH2:14][C:15]([NH2:17])=[O:16])[C:11](=[O:18])[CH2:10]1

参加物

6

反応物 2

HCID 142744722-[4-(Benzyloxy)-2-oxo-2,5-dihydro-1H-pyrrol-1-yl]acetamide2 回HCID 178418361HCID 178418361、化合物

生成物 1

HCID 4626Oxiracetam

試薬・触媒・溶媒 3

HCID 23938Palladium触媒HCID 82844Platinum oxide (PtO)触媒HCID 176Acetic Acid溶媒

実験手順

Catalytic hydrogenolysis and hydrogenation of 4-benzyloxy-3-pyrrolin-2-on-1-yl acetamide 3.00 g of 4-benzyloxy-3-pyrrolin-2-on-1-yl acetamide was dissolved in 30 ml of concentrated acetic acid and mixed with 240 mg of palladium 5 percent on activated carbon and 24 mg of platinum oxide. Hydrogenolysis and hydrogenation at 15 bars of hydrogen pressure and room temperature were performed for 65 hours. Then filtering off from the catalyst and evaporation of the solvent were performed. The residue was picked up in H2O and allowed to run over 5.0 g of weakly basic ion exchanger. The water was distilled off and the residue mixed with 10 ml of acetone. 1.53 g of nearly white 4-hydroxypyrrolidin-2-on-1-yl acetamide with a melting point of 163.5° to 165.7° C. was obtained.

後処理

  1. filtrationThen filtering off from the catalyst and evaporation of the solvent
  2. distillationThe water was distilled off
  3. additionthe residue mixed with 10 ml of acetone

出典と根拠

ORDレコード
ord-1ec0859131be4dbbb5b33508ae58bf95
出典データセット
uspto-grants-1989_06
特許番号
US04843166

反応ノート

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