Pyridine → N-(3-Formamido-2-oxoazetidin-3-yl)-2-phenoxyacetamide
反応式
[NH2:1][C:2]1([NH:7][C:8](=[O:17])[CH2:9][O:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[CH2:5][NH:4][C:3]1=[O:6].N1C=CC=CC=1.[C:24](OC=O)(=[O:26])C>ClCCl>[CH:24]([NH:1][C:2]1([NH:7][C:8](=[O:17])[CH2:9][O:10][C:11]2[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=2)[CH2:5][NH:4][C:3]1=[O:6])=[O:26]参加物
5
実験手順
The amine (27) (66 mg) in dry dichloromethane (5 ml) was cooled to 0° and treated with pyridine (49 mg) followed by formic-acetic anhydride (27 mg). The mixture was stirred at 0° for 15 minutes then allowed to warm to room temperature over 15 minutes, and evaporated to dryness. The residue was chromatographed on silica gel to give the product (28) (53 mg).
後処理
- customevaporated to dryness
- customThe residue was chromatographed on silica gel
出典と根拠
- ORDレコード
- ord-1f2a519fad954e04a0cd2989fc84efa0
- 出典データセット
- uspto-grants-1987_03
- 特許番号
- US04647558
反応ノート
読み込み中…