Sodium Hydroxide → 2-Amino-5-(pyridin-4-yl)-1,3-thiazole-4-carboxylic acid

HRID 1906006ノート

反応式

HRID 1906006 の反応式
[NH2:1][C:2]1[S:3][C:4]([C:12]2[CH:17]=[CH:16][N:15]=[CH:14][CH:13]=2)=[C:5]([C:7]([O:9]CC)=[O:8])[N:6]=1.[OH-].[Na+]>CO.O>[NH2:1][C:2]1[S:3][C:4]([C:12]2[CH:17]=[CH:16][N:15]=[CH:14][CH:13]=2)=[C:5]([C:7]([OH:9])=[O:8])[N:6]=1

参加物

5

反応物 2

HCID 14798Sodium HydroxideHCID 20145021Ethyl 2-amino-5-(pyridin-4-yl)-1,3-thiazole-4-carboxylate

生成物 1

HCID 201449862-Amino-5-(pyridin-4-yl)-1,3-thiazole-4-carboxylic acid収率 79.8%

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 962Water溶媒

実験手順

A mixture of ethyl 2-amino-5-(4-pyridyl)-4-thiazolecarboxylate (5.0 g) and sodium hydroxide (1.6 g) in a mixture of methanol (50 ml) and water (10 ml) was stirred at ambient temperature for an hour. The reaction mixture was evaporated in vacuo and the residue was dissolved in water. The aqueous solution was adjusted to pH 5 with 10% hydrochloric acid. The precipitate was collected by filtration and dried over phosphorus pentoxide in vacuo to afford 2-amino-5-(4-pyridyl)-4-thiazolecarboxylic acid (3.54 g).

後処理

  1. customThe reaction mixture was evaporated in vacuo
  2. dissolutionthe residue was dissolved in water
  3. filtrationThe precipitate was collected by filtration
  4. dry with materialdried over phosphorus pentoxide in vacuo

出典と根拠

ORDレコード
ord-e48138b7789b4b7e92f7b034976d697b
出典データセット
uspto-grants-1987_03
特許番号
US04649146

反応ノート

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