Formic Acid → 2-(N-methylformamido)-4-methyl-5-acetylthiazole
反応式
[CH3:1][NH:2][C:3]1[S:4][C:5]([C:9](=[O:11])[CH3:10])=[C:6]([CH3:8])[N:7]=1.[C:12](OC(=O)C)(=[O:14])C.C(O)=O>O1CCCC1>[CH3:1][N:2]([C:3]1[S:4][C:5]([C:9](=[O:11])[CH3:10])=[C:6]([CH3:8])[N:7]=1)[CH:12]=[O:14]参加物
5
実験手順
To a solution of 2-methylamino-4-methyl-5-acetylthiazole (35 g) in tetrahydrofuran (700 ml) were added a mixture of acetic anhydride (94.5 ml) and formic acid (37.7 ml) at ambient temperature and the mixture was stirred for two hours. The reaction mixture was evaporated in vacuo. The residue was added to water and the resultant precipitate was collected by filtration and dried over phosphorus pentoxide to give 2-(N-methylformamido)-4-methyl-5-acetylthiazole (39.59 g).
後処理
- customThe reaction mixture was evaporated in vacuo
- additionThe residue was added to water
- filtrationthe resultant precipitate was collected by filtration
- dry with materialdried over phosphorus pentoxide
出典と根拠
- ORDレコード
- ord-884dbaa5b4494834b8bee2ff882716a7
- 出典データセット
- uspto-grants-1987_03
- 特許番号
- US04649146
反応ノート
読み込み中…