Trifluoroacetic acid → HCID 178448352、化合物
反応式
[C:1]([OH:7])([C:3]([F:6])([F:5])[F:4])=[O:2].[NH:8](C(OC(C)(C)C)=O)[C@H:9]([C:18]([NH:20][C@H:21]([C:32]([NH:34][C@H:35]([C:51]([NH:53][C@H:54]([C:66]([NH:68][C@H:69]([C:73]([O:75]C(C)(C)C)=[O:74])[CH:70]([CH3:72])[CH3:71])=[O:67])[CH2:55][C:56](=[O:65])[O:57][CH2:58][C:59]1[CH:64]=[CH:63][CH:62]=[CH:61][CH:60]=1)=[O:52])[CH2:36][CH2:37][CH2:38][CH2:39][NH:40][C:41]([O:43][CH2:44][C:45]1[CH:50]=[CH:49][CH:48]=[CH:47][CH:46]=1)=[O:42])=[O:33])[CH2:22][CH2:23][CH2:24][NH:25][C:26](=[NH:31])[NH:27][N+:28]([O-:30])=[O:29])=[O:19])[CH2:10][C:11]1[CH:16]=[CH:15][C:14]([OH:17])=[CH:13][CH:12]=1>C(Cl)Cl>[NH2:8][C@H:9]([C:18]([NH:20][C@H:21]([C:32]([NH:34][C@H:35]([C:51]([NH:53][C@H:54]([C:66]([NH:68][C@H:69]([C:73]([OH:75])=[O:74])[CH:70]([CH3:71])[CH3:72])=[O:67])[CH2:55][C:56](=[O:65])[O:57][CH2:58][C:59]1[CH:64]=[CH:63][CH:62]=[CH:61][CH:60]=1)=[O:52])[CH2:36][CH2:37][CH2:38][CH2:39][NH:40][C:41]([O:43][CH2:44][C:45]1[CH:50]=[CH:49][CH:48]=[CH:47][CH:46]=1)=[O:42])=[O:33])[CH2:22][CH2:23][CH2:24][NH:25][C:26](=[NH:31])[NH:27][N+:28]([O-:30])=[O:29])=[O:19])[CH2:10][C:11]1[CH:16]=[CH:15][C:14]([OH:17])=[CH:13][CH:12]=1.[F:4][C:3]([C:1]([OH:7])=[O:2])([F:6])[F:5]参加物
4
実験手順
For simultaneous splitting off of the Boc and tert.-butyl ester protective groups, 7.4 ml (96 mmol) of TFA are added to 2.65 g (2.4 mmol) of 9 and the mixture is stirred under an N2 atmosphere at room temperature for 10 minutes. The solution is taken up in 50 ml of CH2Cl2 and the mixture is evaporated. The product is then recrystallized from MeOH/diethyl ether and dried over KOH.