Pyridine → Zsb11
反応式
[OH:1][CH2:2][N:3]1[C:8](=[O:9])[CH2:7][N:6]([CH2:10][CH2:11][N:12]2[CH2:17][C:16](=[O:18])[N:15]([CH2:19][OH:20])[C:14](=[O:21])[CH2:13]2)[CH2:5][C:4]1=[O:22].N1C=CC=CC=1.[C:29](OC(=O)C)(=[O:31])[CH3:30].[C:36](OCC)(=[O:38])[CH3:37]>>[C:29]([O:20][CH2:19][N:15]1[C:14](=[O:21])[CH2:13][N:12]([CH2:11][CH2:10][N:6]2[CH2:7][C:8](=[O:9])[N:3]([CH2:2][O:1][C:36](=[O:38])[CH3:37])[C:4](=[O:22])[CH2:5]2)[CH2:17][C:16]1=[O:18])(=[O:31])[CH3:30]参加物
5
実験手順
A mixture of 1,2-bis(4-hydroxymethyl-3,5-dioxopiperazin-1-yl)ethane (1.50 g, 4.8 m mol), pyridine (10 ml) and acetic anhydride (5 ml, 52.9 m mol) was stirred for 12 hours at room temperature. The reaction mixture was diluted with ethyl acetate (20 ml) and the resulting crystals were collected and washed with ethyl acetate and successively with ether and was dried under reduced pressure to give the titled compound (1.34 g; yield 70.5%).