Ammonia → HCID 13885367、化合物

HRID 1906346ノート

反応式

HRID 1906346 の反応式
[N:1]1([S:5]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=2[S:14](F)(=[O:16])=[O:15])(=[O:7])=[O:6])[CH2:4][CH2:3][CH2:2]1.[NH3:18]>C1COCC1>[N:1]1([S:5]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=2[S:14]([NH2:18])(=[O:16])=[O:15])(=[O:7])=[O:6])[CH2:4][CH2:3][CH2:2]1

参加物

4

反応物 2

HCID 222Ammonia2 回HCID 13885366HCID 13885366、化合物

生成物 1

HCID 13885367HCID 13885367、化合物

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

In a 1-l flask was placed 9.8 g. of 2-(azetidin-1-ylsulfonyl)benzenesulfonyl fluoride and 500 ml of THF. Then 9 ml of ammonia was added and the mixture was refluxed for two days. Four 25 ml portions of liquid ammonia were then added to the refluxing solution over a 48 hour period. The reaction mixture was concentrated and the residue chromatographed on silica gel (dichloroethane). The desired product was collected to give 4.9 g of a solid m.p. 121°-123° C.

後処理

  1. customIn a 1-l flask was placed
  2. temperaturethe mixture was refluxed for two days
  3. concentrationThe reaction mixture was concentrated
  4. customthe residue chromatographed on silica gel (dichloroethane)
  5. customThe desired product was collected

出典と根拠

ORDレコード
ord-b4661df4c4b34930b3f74a1af7f87b47
出典データセット
uspto-grants-1987_03
特許番号
US04652304

反応ノート

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