Phosphorus pentachloride → Ethyl 3-(chlorosulfonyl)propanoate
反応式
[C:1]([CH2:6][CH2:7][S:8]([O-:11])(=O)=[O:9])([O:3][CH2:4][CH3:5])=[O:2].[Na+].P(Cl)(Cl)(Cl)(Cl)[Cl:14]>C(Cl)(Cl)Cl>[C:1]([CH2:6][CH2:7][S:8]([Cl:14])(=[O:11])=[O:9])([O:3][CH2:4][CH3:5])=[O:2]参加物
4
実験手順
To a stirred mixture of 90.5 g (0.44 moles) sodium 2-carboethoxyethyl sulfonate (the product of Example 26) in 300 ml chloroform, 92 g (0.44 moles) phosphorus pentachloride was added in small portions, maintaining the temperature of the reaction mixture below 40° C. during the addition. The reaction mixture was refluxed for about 6 hours, and then filtered. Nitrogen was bubbled through the solution to remove excess hydrogen chloride gas. Stripping of the solvent gave 28.4 g of the above-identified product.
後処理
- temperaturemaintaining the temperature of the reaction mixture below 40° C.
- additionduring the addition
- temperatureThe reaction mixture was refluxed for about 6 hours
- filtrationfiltered
- customNitrogen was bubbled through the solution
- customto remove excess hydrogen chloride gas
出典と根拠
- ORDレコード
- ord-c014c098d5a945b49ccac70f88bc95ba
- 出典データセット
- uspto-grants-1987_03
- 特許番号
- US04652556
反応ノート
読み込み中…