Hydrochloric Acid → HCID 13729408、化合物

HRID 1906433

反応式

HRID 1906433 の反応式
[C:1]([C:4]1[O:5][C:6]2[C:12]([O:13][CH2:14][CH:15]3[O:17][CH2:16]3)=[CH:11][CH:10]=[CH:9][C:7]=2[CH:8]=1)(=[O:3])[NH2:2].[ClH:18]>C(Cl)(Cl)Cl>[C:1]([C:4]1[O:5][C:6]2[C:12]([O:13][CH2:14][CH:15]([OH:17])[CH2:16][Cl:18])=[CH:11][CH:10]=[CH:9][C:7]=2[CH:8]=1)(=[O:3])[NH2:2]

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 137294032-Carbamoyl-7-(2,3-epoxypropoxy)benzofuran

生成物 1

HCID 13729408HCID 13729408、化合物

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒

実験手順

There was suspended 2.3 g of 2-carbamoyl-7-(2,3-epoxypropoxy)benzofuran obtained in Reference Example 1 in 70 ml of chloroform, and thereto 15 ml of concentrated hydrochloric acid was added. Thereafter, the mixture was vigorously stirred at room temperature for 15 minutes. After the chloroform layer was washed with water and dried with magnesium sulfate, the solvent was distilled away from the reaction mixture under reduced pressure. The resultant residue was purified by silica-gel chromatography (eluent: 2 % ethanol-chloroform) to give the desired compound.

後処理

  1. washAfter the chloroform layer was washed with water
  2. dry with materialdried with magnesium sulfate
  3. distillationthe solvent was distilled away from the reaction mixture under reduced pressure
  4. customThe resultant residue was purified by silica-gel chromatography (eluent: 2 % ethanol-chloroform)

出典と根拠

ORDレコード
ord-00a4f93f0c5e423b940f80ea6c6f94fd
出典データセット
uspto-grants-1987_03
特許番号
US04652566

関連ノート

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