HCID 14003355、化合物 → HCID 70429469、化合物
反応式
C([NH:8][CH2:9][CH2:10][C:11]([NH:13][C:14]1[CH:19]=[CH:18][C:17]([C:20]2[CH:21]([CH3:27])[CH2:22][C:23](=[O:26])[NH:24][N:25]=2)=[CH:16][CH:15]=1)=[O:12])C1C=CC=CC=1.[CH2:28]([C:31]1[CH:41]=[C:40]([CH2:42][CH2:43][O:44][CH2:45][CH:46]2[CH2:48][CH2:47]2)[CH:39]=[CH:38][C:32]=1[O:33][CH2:34][CH:35]1[O:37][CH2:36]1)[CH:29]=[CH2:30]>C(O)CC>[OH:37][CH:35]([CH:34]([CH2:20][C:17]1[CH:18]=[CH:19][CH:14]=[CH:15][CH:16]=1)[O:33][C:32]1[CH:38]=[CH:39][C:40]([CH2:42][CH2:43][O:44][CH2:45][CH:46]2[CH2:48][CH2:47]2)=[CH:41][C:31]=1[CH2:28][CH:29]=[CH2:30])[CH2:36][NH:8][CH2:9][CH2:10][C:11]([NH:13][C:14]1[CH:15]=[CH:16][C:17]([C:20]2[CH:21]([CH3:27])[CH2:22][C:23](=[O:26])[NH:24][N:25]=2)=[CH:18][CH:19]=1)=[O:12]参加物
4
実験手順
A mixture of 6-[4-(3-benzylaminopropionamido)phenyl]-5-methyl-4,5-dihydro-3(2H)-pyridazinone (5.5 g; 0.015 mol), 1-[2-allyl-4-[2-(cyclopropylmethoxy)ethyl]phenoxy]-2,3-epoxypropane (8.65 g; 0.03 mol) and n-propanol (100 ml) was stirred under reflux for 24 hours. The mixture was cooled, filtered and the filtrate was evaporated under reduced pressure and chromatographed on a silica gel column, using ethyl acetate as eluant, to give as a glass 6-[4-[3-[2-hydroxy-3-[2-allyl-4-(2-(cyclopropylmethoxy)ethyl)phenoxy]-N-benzylpropylamino]propionamido]phenyl]-5-methyl-4,5-dihydro-3(2H)-pyridazinone (4.4 g).