Dihydroxyacetone → 1,3-Dibutyrin

HRID 1906914ノート

反応式

HRID 1906914 の反応式
[OH:1][CH2:2][C:3]([CH2:5][OH:6])=[O:4].[C:7](Cl)(=[O:11])[CH2:8][CH2:9][CH3:10]>N1C=CC=CC=1>[C:7]([O:1][CH2:2][CH:3]([OH:4])[CH2:5][O:6][C:7](=[O:11])[CH2:8][CH2:9][CH3:10])(=[O:11])[CH2:8][CH2:9][CH3:10]

参加物

4

反応物 2

HCID 670DihydroxyacetoneHCID 8855Butyryl chloride

生成物 1

HCID 1229201,3-Dibutyrin

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

実験手順

By following the procedure of Example 1(a) and 1(b) using 13.05 g. of 1,3-dihydroxyacetone, 23.7 g. of pyridine and 31.1 g. of butyryl chloride, 17.9 g. of 1,3-dibutanoyloxy-2-propanol is obtained. The reaction of 12.2 g. of this material and 9.4 g. of valproyl chloride and 4.98 g. of pyridine as described in Example 1(c) yields an oil which is purified by chromatography as described in Example 3. The pure 1,3-dibutanoyl-2-valproyl-glyceride is eluted from the column with petroleum ether/ether (95:5); it is obtained in a yield of 9.1 g.; Rf 0.61 (petroleum ether/ether 3:1); mass spectrum m/e 316 (M+ -42).

出典と根拠

ORDレコード
ord-0d533ae828c945839b89498cd6af0d14
出典データセット
uspto-grants-1987_03
特許番号
US04654370

反応ノート

読み込み中…