1-(4-Methoxy-3-nitrophenyl)-4-methylpiperazine → HCID 24994141、化合物
反応式
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([N:9]2[CH2:14][CH2:13][N:12]([CH3:15])[CH2:11][CH2:10]2)=[CH:5][C:4]=1[N+:16]([O-])=O>CO.[Pd]>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([N:9]2[CH2:10][CH2:11][N:12]([CH3:15])[CH2:13][CH2:14]2)=[CH:5][C:4]=1[NH2:16]参加物
4
実験手順
A solution of 1-(4-methoxy-3-nitro-phenyl)-4-methyl-piperazine (1.0 g, 4.0 mmol) in MeOH (100 mL) in the presence of Pd/C 10% (150 mg) was hydrogenated at 35 psi for 2 h. The mixture was filtered over a pad of celite and the solution was concentrated to afford 0.8 g (90% yield) of the title compound.
後処理
- filtrationThe mixture was filtered over a pad of celite
- concentrationthe solution was concentrated
出典と根拠
- ORDレコード
- ord-d910d48dfb6c450caf5eb7b117c7443e
- 出典データセット
- uspto-grants-2013_12
- 特許番号
- US08598172B2
反応ノート
読み込み中…