Morpholine → HCID 53944659、化合物

HRID 1907706ノート

反応式

HRID 1907706 の反応式
CS([C:5]1[N:10]=[CH:9][C:8]([C:11]([O:13][CH2:14][CH3:15])=[O:12])=[CH:7][N:6]=1)(=O)=O.[NH:16]1[CH2:21][CH2:20][O:19][CH2:18][CH2:17]1>COCCOC.C(Cl)Cl>[O:19]1[CH2:20][CH2:21][N:16]([C:5]2[N:10]=[CH:9][C:8]([C:11]([O:13][CH2:14][CH3:15])=[O:12])=[CH:7][N:6]=2)[CH2:17][CH2:18]1

参加物

5

反応物 2

HCID 8083MorpholineHCID 254889Ethyl 2-(methylsulfonyl)pyrimidine-5-carboxylate

生成物 1

HCID 53944659HCID 53944659、化合物収率 108%

試薬・触媒・溶媒 2

HCID 6344Dichloromethane溶媒HCID 80711,2-Dimethoxyethane溶媒

実験手順

A solution of sulfone 121 (0.184 g, 0.80 mmol) in ethyleneglycol dimethylether (5 mL) was treated with neat morpholine (0.3 mL, 3.4 mmol) and the mixture was stirred at room temperature for 48 h. The reaction mixture was then diluted with DCM and washed with saturated NaHCO3 in brine, dried over MgSO4, filtered, concentrated and stored under vacuum to give intermediate 122 (0.205 g, >99% yield).

後処理

  1. washwashed with saturated NaHCO3 in brine
  2. dry with materialdried over MgSO4
  3. filtrationfiltered
  4. concentrationconcentrated

出典と根拠

ORDレコード
ord-dcd232c1eff14adbb87198f411184f79
出典データセット
uspto-grants-2013_12
特許番号
US08598168B2

反応ノート

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