Hydrochloric Acid → 4-Amino-5-nitropicolinic acid
反応式
C[O:2][C:3](=[O:14])[C:4]1[CH:9]=[C:8]([NH2:10])[C:7]([N+:11]([O-:13])=[O:12])=[CH:6][N:5]=1.[OH-].[Na+].Cl>CO>[NH2:10][C:8]1[C:7]([N+:11]([O-:13])=[O:12])=[CH:6][N:5]=[C:4]([C:3]([OH:14])=[O:2])[CH:9]=1参加物
5
実験手順
A mixture of methyl-4-amino-5-nitropicolinate (200 mg, 1.01 mmol) and NaOH (aq, 1M, 2.0 mL, 2.0 mmol) in methanol was stirred at ambient temperature for 10 min. The mixture was acidified by addition of HCl (aq, 1M, 2.1 mL, 2.1 mmol) and concentrated i. vac. and the aqueous residing mixture filtered. The solid was washed with water and dried i. vac.
後処理
- concentrationconcentrated i
- filtrationand the aqueous residing mixture filtered
- washThe solid was washed with water
- customdried i
出典と根拠
- ORDレコード
- ord-55befc6ebcd748beac40249d533ed487
- 出典データセット
- uspto-grants-2013_12
- 特許番号
- US08598190B2
反応ノート
読み込み中…